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While one trial did show VAX-D to be more effective than TENS, concerns about study design, limited generalizability, and safety risks have kept it from being widely accepted as a standard treatment (Aetna Clinical Policy Bulletins, 2025)
Jett, L., Lger, R., Thibaudeau, K., Benquet, C., Robitaille, M., Pellerin, I., Paradis, V., van Wyk, P., Pham, K., & Bridon, D
In ovarian stromal cells of PCOS patients, LH enhances CYP17A1 phosphorylation via the cAMP/PKA pathway, upregulating 17-hydroxylase and 17,20-lyase activities and leading to excessive production of androstenedione and testosterone ( Moreover, excessive LHCGR activation may trigger premature luteinization of granulosa cells through ERK1/2-mediated phosphorylation, disrupting dominant follicle selection
Annu Rev Immunol (2021) 39:395416
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